If you go with the command set you can use the 10% inc damage to off-set a lower physical mastery. Also the OP bonus provide pretty well for this, as well as our outgoing heal rating.
I am still planning my build for the new moors, but due to the inc healing of creeps, and a significant dps boost, I feel the way to go is Mitigation, inc heal rating, and tactical crit.
Since we rely on hots for heals we need to give ourselves as much time as possible to use them. We have to staunch our morale loss enough for the hots to work. We do that through mitigation and inc heal rating (mainly through relics). Tactical crit with relentless optimism with strength from within will give you a significant increase in self healing, especially now that we have VS in red line.
^These are just my thoughts I'm a long way from testing it.
Last edited by Armitas; Nov 02 2012 at 10:36 AM.